This is a funny bit from Myq Kaplan, with animation from Greg Franklin.
The idea of mixing stand-up and imaginative animation is nothing new, and there's actually plenty of it around. I remember seeing it on Comedy Central once years ago, and then more recently for a bit by Mike Birbiglia.
Kaplan's interesting because he gives a good joke and then has nice follow-up remarks, like the "too soon?" after the pyramids in Egypt line. I like that because it comes off as unassuming yet wry.